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A literature review of disease-modifying osteoarthritis drugs (DMOADs) and their potential to repair/regenerate tissues was published in the Archives of Bone and Joint Surgery. Most OA treatments are aimed at pain reduction and researchers noted:
- Surgical treatments include: joint distraction...
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What are the major causes of sciatica? What treatments—such as NSAIDs, acetaminophen, systemic corticosteroids, epidurals, exercise therapy, surgery—work best for sciatica? What about prevention? Researchers, publishing their findings in Cureus, reviewed articles to uncover the most effective aids...
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The 2016 Centers for Disease Control and Prevention Guideline for Prescribing Opioids for Chronic Pain was controversial; did it change minds? Apparently it did get practitioners to think “nonopioids” more often. An article published in JAMA Network Open presented information based on cohort study...
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Why/how do NSAIDs do what they do? They are used for their anti-inflammatory effects, but is that all? Research published in Immunity examined an NSAID subset that activates nuclear factor erythroid 2-related factor 2 (NRF2). NRF2 controls some genes that participate in processes including...
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NSAIDs are available everywhere over the counter, but do purchasers understand the potential risks involved? Dr. Paul Christo, an associate professor at Johns Hopkins University School of Medicine, advises discussions between patients and practitioners.
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After thoracic surgery, chronic neuropathic pain is common—3 months postsurgery, the rate of postthoracotomy pain syndrome (PTPS) is over half; at 6 months, 47%. Symptoms/complications include shooting/burning pain, shocking, and aching pain that can last years. A study published in the Journal of...
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Postoperative pain in adults. Which is better for pain relief after outpatient surgery, NSAIDs or codeine? An article published in the Canadian Medical Association Journal, or CMAJ, detailed the results of a systematic review and meta-analysis, with patient pain scores as the primary outcome and...
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The Journal of Emergency Nursing published an article reviewing data from emergency departments regarding ankle sprains and medications. What was administered and prescribed to those going to the ED for treatment? Researchers reviewed electronic medical records for information pertaining to opioids...
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NSAIDs, a common pain reliever and fever reducer, should not be taken by women after 20 weeks into their pregnancy. So says the FDA, due to the fact that NSAIDs “can lead to low levels of amniotic fluid surrounding the baby” and harm the kidney of the fetus. It’s a rare but serious condition. It was...
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New guidelines and recommendations from the American College of Physicians and American Academy of Family Physicians are outlined in Annals of Internal Medicine. Specifically, the guidelines examine how best to combat adult acute pain from musculoskeletal injuries via both pharmacologic and...