| Article
Ketamine has been in clinical use for over 30 years. It has an excellent safety profile and profound analgesia. In the operating room, we really like it for specific populations. It’s related to the drug PCP and it does have some psychomimetic effects which is actually one of the reasons it’s not...
| Article
Aura is basically secondary to what has been termed the cortical spreading depression, and what that means is that you have oligemia. You have blood flow decrease starting at the back in the brain and it moves forward. With this cortical spreading depression, the oligemia--the decreased blood flow-...
| Article
We know that migraine is a neurological vascular headache and, more importantly, it’s a disease of the brain. That’s basically what we understand now from what we understand about migraine, and it is associated in a number of migraine patients with central sensitization. That means that the pain...
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A 2-part discussion of chronic headache; differential diagnosis and treatment approaches.
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Migraine is one of the most prevalent and disabling medical conditions. Dr. Dodick discusses the impact on quality of life, the pathophysiology of migraine, and new areas of therapeutic focus.
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Understanding the genetic underpinnings of the disease is really key to developing new drug targets and new therapies. Right now we have at least four autosomal dominant genes that have been identified to account for at least some of the rarest subtypes of migraine, and some genome-wide association...