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In an article published last month in PloS One, researchers studying 155 outpatients with major depressive disorder found that “Compared with the migraine with inactive headache group and the non-migraine group, patients with migraine with active headache had significantly higher intensities of...
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The incidence of migraine is 3 times higher in women than in men, and findings from a recent preclinical study conducted at the University of Texas, Dallas may shed light on the reason why. Working with rodent models, researchers introduced calcitonin gene-related peptide (CGRP), a protein...
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Findings from a recently completed meta-analysis suggest that obese migraine sufferers can reduce the incidence and severity of migraine attacks and improve their quality of life by losing weight. Lead author Claudio Pagano, MD, PhD, associate professor of internal medicine at the University of...
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Migraine is among the most disabling disorders in the world, and much of the treatment armamentarium to date comes with significant unwanted effects. But new advances in our understanding of neurotransmitters and sensory processing may have led us to the dawn of a new and better era of migraine...
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Botulinum toxin, usually referenced by the brand name Botox®, received FDA approval as a treatment for chronic migraine in 2010. An updated review and meta-analysis of pooled clinical trial data now provides further confirmation of its efficacy, concluding that Botox is superior to placebo for the...
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Researchers from the Center for Applied Genomics at Children’s Hospital of Philadelphia report the discovery of gene variants that are associated with elevated risk for migraine in African-American children. The authors state that the findings may inform the development of targeted treatments for...
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A data review conducted by researchers from the Instituto de Biología Molecular y Celular, Universitas Miguel Hernández, Elche, Spain concludes that sex hormones may contribute to modulation of transient receptor potential (TRP) channels’ expression and activity, thereby impacting sensitization in...
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Conclusions from a recent cross-sectional study investigating the association between diabetes mellitus and migraine found no significant differences in the prevalence of migraine between age- and sex-matched diabetic and nondiabetic subjects, after adjusting for possible confounding variables. The...
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Approximately 1 billion people in the world are affected with migraine and the thought is that about 40% of them that are candidates for some type of preventative therapy. A sizable proportion of that 40% doesn’t actually receive the kind of preventative therapy that they need, and so that equates...
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Headache, by itself, is just a symptom. It’s like saying someone has arm pain; there are many causes of arm pain. There are over 300 different causes of headache; some of them are threatening, secondary headaches; some of them are not threatening but problematic--those are primary headaches. Once...