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The journal of Science reports findings from researchers accessing chemotypes from a virtual library of over 300 million molecules. The authors of the study “computationally docked each virtual molecule into the highly similar α2BAR binding site, prioritizing those that physically fit and that were...
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The journal of Rheumatology and Therapy published a report on the first use of mediation modeling* to explore psoriatic arthritis and its relationship to pain and inflammation: does tofacitinib help? Data from 2 studies of psoriatic arthritis patients was pooled; patients were treated with a placebo...
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The Indian Journal of Critical Care Medicine reports findings from 2 cases of rare mesenteric panniculitis (MP)—inflammation of mesentery fat—in patients during their second week of having COVID. Although 1 of the patients had a mild case and the other severe, both experienced higher inflammatory...
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The journal of Plants (Basel) reported on a review of neuropathic pain and its potential alleviation due to cannabinoids. This study specifically investigated cannabinoid administration routes other than oral or inhaled. As the research into the treatment of neuropathic pain grows along with its...
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Why/how do NSAIDs do what they do? They are used for their anti-inflammatory effects, but is that all? Research published in Immunity examined an NSAID subset that activates nuclear factor erythroid 2-related factor 2 (NRF2). NRF2 controls some genes that participate in processes including...
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The COVID pandemic hampered in-person healthcare visits for many patients. A study in Archives of Physical Medicine and Rehabilitation assessed healthcare disruption and telehealth use among 70 persons with multiple sclerosis (pwMS) and 93 healthy controls during the COVID-19 pandemic. Among young...
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In a New England Journal of Medicine online editorial, a professor/hematologist commented on a study about sickle cell disease and gene therapy. The study, which also appeared in NEJM, successfully prevented complications from the disease by adding a gene to a patient’s blood stem cells. “Gene...
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The chronic inflammatory pain condition primary Sjögren's syndrome (pSS) causes dry mouth and eyes, pain and fatigue, and depression and anxiety. A study published in the Journal of Internal Medicine reports on the health related quality of life (HRQoL) cost for people in the United Kingdom with pSS...
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According to the CDC, OA affects over 32.5 million US adults. Discovery of a new molecular signaling pathway, therefore, could be important. The research, published in Frontiers in Neuroscience, presents “the first evidence of a potential functional role of artemin/GFRα3 in chronic OA-pain in mice...
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As colorectal cancer occurrences in people under age 50 increase, researchers have developed a risk prediction model. The study, published in the Journal of the National Cancer Institute, hopes to identify those at risk well before they experience abdominal pain, rectal bleeding, low blood counts...