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An article in January’s Journal of Pain discussed ibuprofen, a highly used analgesic. Due to its slow absorption, however, just how well does it work on acute moderate to severe pain? Researchers presented findings on the relatively new L-arginine salt-containing ibuprofen to determine its efficacy...
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A systematic review published in BMJ Open looked at the use of analgesic doses of ketamine to assess its efficacy and safety compared with other analgesic drugs (or no drug) in adult prehospital patients with acute pain. Culling information from clinical trials, the researchers included 8 studies...
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In an online edition of the British Journal of Anaesthesia, the Perioperative Pain and Addiction Interdisciplinary Network—or PAIN—outlined recommendations for patients who use cannabis. The regulation and use of marijuana products is constantly evolving. Cannabis use can alter perioperative...
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The journal Children discussed a study of low English proficiency (LEP) and pain management for pediatric patients who had appendectomies at a hospital in San Francisco. Although LEP and English proficient (EP) groups received the same amount of opioid medication intraoperatively, the LEP patients:
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An article in the journal of Social Cognitive and Affective Neuroscience states that people who take over the counter acetaminophen feel less scared, less negative, and potentially more willing to do risky things. In multiple studies discussed, people were given acetaminophen or placebo, and asked...
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Over-the-counter analgesics are easy to access and are, for many, a way to control pain. However, a study published in the journal of Pharmacoepidemiology and Drug Safety brought to light some sobering statistics. Almost half a million suicide related cases called in to Poison Control Centers in the...
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Every year in the United States, 250,000 adults and children go through having an appendectomy. Unfortunately, complication rates from the surgery are as high as 15%. Is nonoperative management an option? Yes, according to the literature, which reports a success rate as high as 75% at 1 year. A JAMA...
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From the European Journal of Medicinal Chemistry
Highlights:
• We describe a novel class of diethylaminocarbonyl-2-benzenesulfamide analogs to acetaminophen/paracetamol.
• Compounds, 3b and 3r, lack the hepatotoxicity present in acetaminophen/paracetamol.
• 3b and 3r maintain analgesia...
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Medicine and science builds and grows on the foundations of what has come before. Although pain management discoveries have been at a relative snail’s pace, there have been recent advances in existing medications and analgesic devices, as well as exciting new molecules and formulations on the...
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As clinicians and patients scramble for opioid analgesic alternatives and ways to blunt opioid withdrawal, kratom (also known as mitragynine) use among desperate patients has surged. What should practitioners know?
- Kratom is not part of the usual standard test for urine screens
- At low doses...