He SAID, She SAID. What's the Deal with NSAIDs?

Safety concerns, new warnings, and new formulations focused on harm reduction have led many providers to question NSAIDs place in therapy. NSAIDs have been a cornerstone of pain management of inflammatory, connective tissue, and autoimmune disorders for over a hundred years. A historical perspective is key to understanding the role of NSAIDs in pain management, and a therapeutic update on current evidence will aid providers in practical utilization. The safety of NSAIDs will be reviewed and compared to risks of other medications including opioids. New FDA warnings on cardiovascular risk of NSAIDs will be placed into context and examples of clinical decision-making provided. In addition, new formulations of NSAIDs will be discussed including IV NSAIDs, topical NSAIDs, and new micronized NSAIDs.